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Pragmatic trials are those that are designed to inform real-world clinical practice. They are typically characterized by a focus on the practical aspects of the research design, like the recruitment and consent process in adherence, as well as the use of commonly available equipment.

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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for 프라그마틱 슬롯 사이트 pragmatic trials to be valid and also reduces bias in the results. Too much heterogeneity, however, can cause problems with the design of the trial.

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Pragmatic Play has earned a name for itself by providing high-quality games and a superior user experience. Its software can be used on mobile devices and in multiple languages. Despite its relatively young age it has already established itself as a premier casino gaming platform. Wolves is one of its latest releases, a 5-reel slot machine with a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to mimic real-life scenarios and to achieve maximum validity externally. They are usually requested by practitioners and policymakers to inform their decisions. They are also a good way to identify the cause-effect relationship between an intervention and its outcomes. They should, however, not, be used to replace the need for explanation studies.

The pragmatism idea is controversial and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made the distinction between explanation studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials, that inform the practice and policy decision-making. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic trial which includes recruitment, design and delivery of the intervention, and monitoring.

There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, limited to randomized controlled trials (RCTs) produced 34 articles, shown in red in Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to remember that the majority were conducted in primary care settings.