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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are often characterized as focusing on practical aspects of study design which include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and had participants from different geographic areas. This kind of heterogeneity is required for pragmatic trials to be able to prove their validity and also helps reduce bias in the results. A high degree of heterogeneity, however could cause issues with the trial design.

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The purpose of pragmatic trials is to mimic real-life situations and achieve the highest level of validity externally. They are usually requested by policy makers and practitioners to inform their decision making. They can be used to determine the causality of an intervention with its outcomes. They should not, however be used to replace the need for explanation studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace explanatory tests or 프라그마틱 무료 슬롯 무료슬롯, click here now, if they should serve as an alternative to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the practice and policy decision-making. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool was designed to define the features of a practical trial that include the recruitment process, the design and implementation of the intervention, as well as the follow-up.

There is an encouraging trend in the number of pragmatic trials published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note that the majority of studies were conducted in primary care settings.